When designing data science (DS) pipelines, end-users can get overwhelmed by the large and growing set of available data preprocessing and modeling techniques. Intelligent discovery assistants (IDAs) and automated machine learning (AutoML) solutions aim to facilitate end-users by (semi-)automating the process. However, they are expensive to compute and yield limited applicability for a wide range of real-world use cases and application domains. This is due to (a) their need to execute thousands of pipelines to get the optimal one, (b) their limited support of DS tasks, e.g., supervised classification or regression only, and a small, static set of available data preprocessing and ML algorithms; and © their restriction to quantifiable evaluation processes and metrics, e.g., tenfold cross-validation using the ROC AUC score for classification. To overcome these limitations, we propose a human-in-the-loop approach for the assisted design of data science pipelines using previously executed pipelines. Based on a user query, i.e., data and a DS task, our framework outputs a ranked list of pipeline candidates from which the user can choose to execute or modify in real time. To recommend pipelines, it first identifies relevant datasets and pipelines utilizing efficient similarity search. It then ranks the candidate pipelines using multi-objective sorting and takes user interactions into account to improve suggestions over time. In our experimental evaluation, the proposed framework significantly outperforms the state-of-the-art IDA tool and achieves similar predictive performance with state-of-the-art long-running AutoML solutions while being real-time, generic to any evaluation processes and DS tasks, and extensible to new operators.